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Your Position: Start > FGF acidic

FGF acidic

Brief Information

Name:Fibroblast growth factor 1
Target Synonym:Fibroblast Growth Factor 1 (Acidic),HBGF1,Acidic fibroblast growth factor,Heparin-binding growth factor 1,HBGF-1,Endothelial cell growth factor,FGF1,Fibroblast Growth Factor 1,Endothelial Cell Growth Factor, Alpha,Endothelial Cell Growth Factor, Beta,FGF-1,AFGF,FGFA,ECGF,Beta-Endothelial Cell Growth Factor,ECGF-Beta,FGF-Alpha,GLIO703,ECGFA,ECGFB
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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AFF-H4116 Human Human FGF acidic Protein, Tag Free
AFF-H4116-structure
AFF-H4116-sds
ACRO Quality

Part of Bioactivity data

AFF-H4116-BLI
FGF acidic BLI

Loaded Biotinylated Heparin on SA Biosensor, can bind Human FGF acidic, Tag Free (Cat. No. AFF-H4116) with an affinity constant of 186 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

FGF1,AFGF,ECGF,ECGF-beta,ECGFA,ECGFB,FGF-alpha,FGFA,GLIO703,HBGF1

Background

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLC¦Ã/PKC, and PI3K/Akt pathways.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Solid tumours; Liver Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Solid tumours; Liver Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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